TDP: A Protein Involved in DNA Damage Response and Drug Development

Target Name: Tyrosyl-DNA phosphodiesterase TDP

NCBI ID: P48738

Tyrosyl-DNA phosphodiesterase TDP

Other Name(s): TDP

TDP: A Protein Involved in DNA Damage Response and Drug Development

Tyrosyl-DNA phosphodiesterase TDP (TDP) is a protein that is expressed in various cell types of the human body, including the brain, heart, and kidneys. It is a key enzyme in the DNA damage response pathway, which is involved in the regulation of DNA replication, repair, and degradation. TDP is also known as nonspecific subtype TDP, because it is a subclass of the DNA damage-specific TDP enzyme that is responsible for the repair of single-base DNA damage.

TDP is a protein that consists of 254 amino acids and has a molecular weight of 31 kDa. It has a single catalytic active site and is located at the intersection of DNA and RNA, where it can interact with both. Its structure is composed of a catalytic core and a transmembrane region that is formed by a single transmembrane 伪-helix. The catalytic core of TDP consists of a single alpha helix, which is formed by the interaction of the amino acids that make up the protein. This region is responsible for the catalytic activity of TDP, as well as its ability to interact with DNA and RNA.

TDP is involved in the repair of a wide range of DNA damage types, including single-base damage, double-base damage, and base substitutions. It is also involved in the regulation of DNA replication, repair, and degradation. TDP plays a key role in the repair of single-base DNA damage, as it is able to recognize the damage and recruit the necessary repair machinery to repair it. It is also involved in the regulation of DNA replication, as it is able to interact with the enzyme responsible for DNA replication, called DNA polymerase.

TDP is also involved in the regulation of the expression of genes. It has been shown to play a role in the regulation of the expression of the gene involved in the development and progression of cancer, as well as the regulation of stem cell proliferation. TDP has also been shown to play a role in the regulation of the expression of genes involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

TDP is a protein that is expressed in various cell types of the human body, and it is involved in the regulation of a wide range of cellular processes. Its function as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for various diseases.

In conclusion, Tyrosyl-DNA phosphodiesterase TDP is a protein that is involved in the regulation of various cellular processes and is expressed in a wide range of cell types of the human body. Its role in the DNA damage response pathway, as well as its involvement in the regulation of DNA replication, repair, and degradation, makes it an attractive target for researchers to study and develop new treatments for various diseases. Further research is needed to fully understand the function of TDP as a drug target or biomarker and to develop new treatments for diseases that are caused by TDP-related mechanisms.

Protein Name: Tyrosyl-DNA Phosphodiesterase TDP (nonspecified Subtype)

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